Teams
Infectious agents, resistance and chemotherapy (AGIR)
Study and synthesis of peptides to fight Gram-negative bacteria resistance.
Contact : Alexandra DASSONVILLE-KLIMPT.
Keywords : antibacterial, antimalarial, resistance, peptide/membrane interactions, vectorisation
BIND - Institut FEMTO-ST / Equipe BioINterfaces et Dispositifs
Use of antimicrobial peptides in surface protection against biofilm proliferation; we also produce & use PAMs in biotechnology to produce proteins (soluble-membrane)/vesicles of interest.
Contact: Vincent HUMBLOT.
Keywords: Biointerfaces, lab-on-chip/organ-on-chip, microfluidic devices
BioMat - Biomaterials and Bioengineering
Description of research activities related to AMPs (one sentence):
We are designing innovative antimicrobial, anti-inflammatory and antiviral materials and coatings and evaluating their applications in implantable and non-implantable medical devices using supramolecular assemblies of biopolymers and peptides.
Contact : Philippe Lavalle
Keywords: Biomaterials / Antimicrobials / Biopolymers / Advanced and Smart Materials
Biology of the egg and physiology of the laying hen (BOPP)
(i) formation of natural defenses of the chicken egg, (ii) their evolution as a function of rearing conditions and during storage and/or incubation, and (iii) the identification and characterization of antimicrobial proteins and peptides in the various egg compartments.
Contact : Nicolas GUYOT.
Keywords : Table egg, hatching egg, hygienic quality, antimicrobial peptides and proteins, defensins
CBSA - Lab. of Bacterial Communication and Anti-infective Strategies
Identification of natural or synthetic peptides for their antibacterial, anti-resistance, anti-biofilm, anti-virulence and anti-inflammatory activities, and deciphering their mechanism of action. Contact: Olivier LESOUHAITIER. Keywords: Biofilm, membrane destabilization, ESKAPEE, antibio-resistance, anti-infectious strategies
CBM - Centre de Biophysique Moléculaire / Equipe RMN des Biomolécules
Our projects focus on the 3D NMR structures, structure-function relationships and mechanisms of action of antimicrobial peptides rich in disulfide bridges, in particular defensins. NMR metabolomics and fluorescence microscopy complement our initial expertise in structural biology.
Contact : Céline LANDON.
Keywords: Defensin, NMR, structural biology, structure-activity relationships, mechanism of action, flurorescence microscopy
CBMN - Institute of Chemistry & Biology of Membranes & Nano-objects / Multi Scale Biophysics / Nano-Biotechnology and methodological developments in Atomic Force Microscopy
Nanoscale effects of antimicrobial agents by AFM.
Contact : Sofiane EL-KIRAT-CHATEL.
Keywords : Physico-chemical properties of microbial surfaces, single-molecule force spectroscopy, single-cell force spectroscopy, AFM
COM - Equipe Chimie Organique et Médicinale
Bio-inspired design of molecular architectures, mimicking AMPs, to combat bacterial infections.
Contact: Sophie FAURE.
Keywords: Peptidomimetics, Foldamers, Antimicrobial agents
DGIMI - Diversity, Genomes & Microorganisms Insects Interactions
Role of PAMS from Xenorhabdus/Photorhabdus, entomopathogenic bacteria living in symbiosis with soil nematodes, in biocontrol against insect crop pests. Contact: Alyssa Carré-Mlouka. Keywords: entomopathogenic bacteria, nematodes, microbial ecology, NRPS specialized metabolites, intreactions.
EBI - Ecology & Biology of Interactions
Analysis of the innate immune response of non-model organisms and characterisation of the mode of action of newly identified antimicrobial peptides.
Contact : Julien VERDON.
Keywords : Biological control, Legionella pneumophila, mechanism of action, data mining, insects and crustaceans
GEC - Unité de Génie Enzymatique et Cellulaire UMR 7025 CNRS, Université de Picardie Jules Verne
Description of research activities related to AMPs (one sentence): We use solid and liquid-state NMR and Molecular Dynamic simulations to provide a detailed description of the mechanism of action of antimicrobial and anticancer peptides targeting biological membranes.
Contact: Nicola D’AMELIO.
Keywords: NMR, Molecular dynamics, structural biology, membranes
I2BC - Team Enzymology and non ribosomal peptide biosynthesis
Our team studies diketopiperazines, which are constituted of two amino acids cyclized and further modified, and display varied biological activities.
Contact: Céline AUBRY.
Keywords: Diketopiperazines, CDPS, tRNA, cytochromes P450s
I2CT - Immunologie, Immunopathologie et Chimie Thérapeutique
Functionalization of nanoparticles for biomedical applications, for example with antimicrobial peptides.
Contact: Cécilia MENARD-MOYON.
Keywords: nanoparticles, functionalization, self-assembly, hydrogels, biomedical applications
Paris-Seine Institute of Biology / Biogenesis of Peptide Signals (IBPS / BIOSIPE)
Structural and functional characterization of amphibian AMPs and valorization as therapeutic agents.
Contact : Ali LADRAM.
Keywords : Amphibians - dermaseptins – temporins – structure-activity relationship – mechanism of action
ICSN - Institute of Natural Product Chemistry / Plant Metabolites Team
medicinal chemistry projects based on cyclopeptides isolated from plants, with strong antiviral activity against a wide range of viruses such as ZIKV, DENV and CHIK.
Contact: Sandy DESRAT.
Keywords:Natural products, Phytochemistry, Medicinal chemistry, Total synthesis, Solid phase peptide synthesis
IRSD - Digestive Health Research Institute
Pathovars of Escherichia coli and commensal and probiotic E. coli; interactions within the intestinal microbiota, in particular through anti-microbial peptides such as siderophore-microcins.
Contact: Frederic AUVRAY et Sophie DUQUESNE.
Keywords: Escherichia coli, commensalism, pathogenicity, microcins, intestinal microbiota
ISM2 - Institut des Sciences Moléculaires de Marseille, Team : Biosciences
Identification and characterization of natural and/or synthetic molecules possessing therapeutic values (including antibacterial, antifungal, antitumoral, anti-inflammatory).
Contact: Marc MARESCA.
Keywords: Chemo-biology interface, peptides, peptidomimetics, therapeutic activities
Infectiology and Public Health (ISP / AIM)
Quantitative screening of antiparasitic activities in vitro (anticoccidial and anti-cryptosporidium activities).
Contact : Anne SILVESTRE.
Keywords : Eimeria / Cryptosporidium / antimicrobial peptides / innate immunity
ISP - Unit Infectious Diseases and Public Health INRAE – University of Tours / Team Microbiota, Monogastric and Salmonella
Models of Salmonella infection in chicken and in mice, in vitro (cell lines and primary cells), ex vivo (enteroids), and in vivo for testing AMPs.
Contact: Anne-Christine LALMANACH.
Keywords: Gallus gallus, Mus musculus, intestinal immunity, Salmonella, infection
LBM - Laboratoire des Biomolécules
Peptide/membrane interactions: structural approaches targeting both the peptide and the molecules surrounding it
Contact: Dror WARSCHAWSKI.
Keywords: Structure, Membranes, NMR, Mass spectrometry, Fluorescence
LIENSs - LIttoral, ENvironment and Societies - UMR 7266 CNRS and La Rochelle University
Characterization of the activities of molecules produced by marine bacteria: antibacterials, antibiofilms and anticancer agents.
Contact: Sophie Sablé.
Keywords: antibacterial, antibiofilm, bacteriocins, NRPS, marine bacteria
MCAM / BIM - Molecules of Communication and Adaptation of Microorganisms - Team Biochemistry of Microbial Interactions
Antimicrobial peptides produced by bacteria: structures, biosynthesis, structure-activity relationships, resistance mechanisms and potential as therapeutic alternative to antibiotics face to the antibiotic resistance crisis.
Contact : Séverine ZIRAH.
Keywords: Bactériocins, ribosomally synthesized and post-translationally modified peptides (RiPPs), non-ribosomal peptides, biosynthesis, intestinal microbiota
MERSEA - Marine Ecosystem and research lab
Etude de la réponse immunitaire chez les organismes marins par des approches multi-omiques. Identification de nouveaux PAMs via le développement de PepTRAQ. Contact : Céline Zatylny-Gaudin. Mots clé : Organismes marins, immunité innée, omics, PepTRAQ
OLGRAM
We develop new AMPs to cure chronic infections by destroying the bacteria at the root of the relapses.
Contact: Pierre ROCHETEAU.
Keywords: persistent bacteria, chronic infectious, antipersister molecule, immunostimulation
